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Introduction
This is the website of the GENOMOS Consortium, initially launched as a EU-sponsored project on the genetics of osteoporosis and which has expanded to a research collaboration between 20 research groups worldwide.
Aims
Osteoporosis is a common, age-related disease with a strong genetic
component. With increasing age of the population, Europe (and the world
in general) is facing a substantial increase in osteoporotic fractures,
which account for considerable disease-burden and costs.
Early identification and treatment of subjects at risk can help preventing this. Gene polymorphisms which predipose to osteoporosis are the most promising risk factors.
The AIM of the project is to identify osteoporosis risk gene polymorphisms. Such genetic risk factors will be studied in interaction with calcium-intake and response to treatment with hormone replacement therapy. Prospective meta-analysis of the largest population studies on osteoporosis is used to develop sufficient power to detect small, but clinically important risks. The project will ultimately constitute a collection of osteoporosis risk-alleles with quantified risks. Identifying such genetic markers is expected to improve the clinical risk-assessment for osteoporosis.
GENOMOS is a European Union Fifth Framework Package funded project,
registered under grans agreement number: QLK6-CT-2002-02629